4-Pyridinemethanamine → 1-(3-Fluorophenyl)-3-(pyridin-4-ylmethyl)thiourea

HRID 1763565

Reaktionsgleichung

Reaktionsgleichung von HRID 1763565
[NH2:1][CH2:2][C:3]1[CH:8]=[CH:7][N:6]=[CH:5][CH:4]=1.NC[C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([CH3:17])[N:12]=1.NCCC1C=CC(CC)=CN=1.NC1C(C)=NC=C(CN)C=1.NCC1C(Cl)=CC=CN=1.NCC1C=C(C2C=CC=CC=2)C=CN=1.NCC1C=C(CC2C=CC=CC=2)C=CN=1.NCC1C=C(OC)C=CN=1.NCC1C=C([S:95][CH3:96])C=CN=1.[N+](C1C=NC=CC=1)([O-])=O.NCC1C(NCC)=CC=CN=1.NCC1C(N(CC)CC)=CC=CN=1.NCC1C=C(NC(=O)C)C=CN=1.NCC1C=C(C(F)(F)[F:151])C=CN=1>>[F:151][C:11]1[CH:17]=[C:13]([NH:12][C:96]([NH:1][CH2:2][C:3]2[CH:8]=[CH:7][N:6]=[CH:5][CH:4]=2)=[S:95])[CH:14]=[CH:15][CH:16]=1

Komponenten

15

Edukt 14

HCID 773174-PyridinemethanamineHCID 1376303-NitropyridineHCID 246721(6-Methylpyridin-2-yl)methanamineHCID 3682810[4-(Trifluoromethyl)pyridin-2-yl]methanamineHCID 156191875-(Aminomethyl)-2-methylpyridin-3-amineHCID 198635004-Phenyl-2-pyridinemethanamineHCID 203104462-(Aminomethyl)-3-diethylaminopyridineHCID 20310472N-(2-(Aminomethyl)pyridin-4-yl)acetamideHCID 203104802-(Aminomethyl)-4-methylthiopyridineHCID 203104822-(5-Ethylpyridin-2-YL)ethanamineHCID 203104882-(Aminomethyl)-3-ethylaminopyridineHCID 203105032-(Aminomethyl)-4-benzylpyridineHCID 21280361(3-Chloropyridin-2-yl)methanamineHCID 22292761(4-Methoxypyridin-2-yl)methanamine

Produkt 1

HCID 7975291-(3-Fluorophenyl)-3-(pyridin-4-ylmethyl)thiourea

Versuchsvorschrift

Similarly, following the above procedure but replacing the 4-aminomethylpyridine as used therein with an equal molar proportion of 2-aminomethyl-6-methylpyridine, 2-(2-aminoethyl)-5-ethylpyridine, 3-amino-5-(aminomethyl)-2-methylpyridine, 2-(aminomethyl)-3-chloropyridine, 2-(aminomethyl)-4-phenylpyridine, 2-(aminomethyl)-4-benzylpyridine, 2-(aminomethyl)-4-methoxypyridine, 2-(aminomethyl)-4-methylthiopyridine, 2-aminomethyl)-3-nitropyridine, 2-(aminomethyl)-3-ethylaminopyridine, 2-(aminomethyl)-3-diethylaminopyridine, 2-(aminomethyl)-4-acetylaminopyridine, and 2-(aminomethyl)-4-trifluoromethylpyridine, respectively, all of which may be prepared by reduction of the corresponding nitrile of formula (IVC) according to the method of Sculley, et al., supra., there is obtained

Aufarbeitung

  1. custom, there is obtained

Quellen und Nachweise

ORD-Eintrag
ord-3827ead1dea846eeb89074e908757f56
Quelldatensatz
uspto-grants-1978_09
Patentnummer
US04112100

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