Ethanolamine → N-(2-hydroxyethyl)-2,4-dimethylbenzenesulfonamide

HRID 1763754Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1763754
[CH2:1]([CH2:3][NH2:4])[OH:2].C(N(CC)CC)C.[CH3:12][C:13]1[CH:18]=[C:17]([CH3:19])[CH:16]=[CH:15][C:14]=1[S:20](Cl)(=[O:22])=[O:21]>O1CCCC1>[OH:2][CH2:1][CH2:3][NH:4][S:20]([C:14]1[CH:15]=[CH:16][C:17]([CH3:19])=[CH:18][C:13]=1[CH3:12])(=[O:22])=[O:21]

Komponenten

5

Edukt 3

HCID 700EthanolamineHCID 8471TriethylamineHCID 69109Benzenesulfonyl chloride, 2,4-dimethyl-

Produkt 1

HCID 15942937N-(2-hydroxyethyl)-2,4-dimethylbenzenesulfonamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel2×

Versuchsvorschrift

To 40 parts of tetrahydrofuran are added 1.5 parts of ethanolamine and 2.5 parts of triethylamine. Into this solution, 10 parts of tetrahydrofuran containing 5 parts of 2,4-dimethylbenzenesulfonyl chloride is dropped with stirring. After the dropping, the resultant mixture is stirred as it is for 30 minutes. Subsequently, the salt is removed by filtration, and the filtrate is freed from the solvent to form a solid. This solid is recrystallized from isopropyl ether to obtain 3.6 parts of N-2-hydroxyethyl-2,4-dimethylbenzenesulfonamide, m.p. 70°-72° C.

Aufarbeitung

  1. customSubsequently, the salt is removed by filtration
  2. customto form a solid
  3. customThis solid is recrystallized from isopropyl ether

Quellen und Nachweise

ORD-Eintrag
ord-56e5dd4761ec402d917d14bccafa9628
Quelldatensatz
uspto-grants-1978_09
Patentnummer
US04113463

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