2-Methylbenzenesulfonic acid → HCID 20307437, Verbindung

HRID 1763778Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1763778
[CH2:1]([N:4]([CH2:9][CH:10]([O:13][CH3:14])[O:11][CH3:12])[C:5](=[O:8])[CH2:6][Cl:7])[C:2]#[CH:3].C1(C)C(S(O)(=O)=O)=CC=CC=1.C(=O)([O-])[O-].[Na+].[Na+]>C(O)C>[CH2:1]([N:4]([CH2:9][CH:10]1[O:11][CH2:12][CH2:14][O:13]1)[C:5](=[O:8])[CH2:6][Cl:7])[C:2]#[CH:3]

Komponenten

5

Edukt 3

HCID 69252-Methylbenzenesulfonic acidHCID 10340Sodium CarbonateHCID 20307409HCID 20307409, Verbindung

Produkt 1

HCID 20307437HCID 20307437, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

N-Propargyl-N-(2,2-dimethoxyethyl)-α-chloroacetamide (8.5 grams), ethandiol-1,2 (2.16 ml) and trace amounts of toluenesulfonic acid were charged into a glass reaction vessel equipped with a mechanical stirrer, thermometer and reflux condenser. The reaction mixture was heated at reflux until no more ethanol was given off. After this time sodium carbonate (1 gram) was added to the mixture with stirring and the resulting mixture was distilled to yield the desired product N-propargyl-N-(1,3-dioxolan-2-ylmethyl)-α-chloroacetamide having a boiling point of 160° to 165° C. at 1 mm of Hg pressure.

Aufarbeitung

  1. additionwere charged into a glass reaction vessel
  2. customequipped with a mechanical stirrer
  3. temperaturethermometer and reflux condenser
  4. temperatureThe reaction mixture was heated
  5. distillationthe resulting mixture was distilled

Quellen und Nachweise

ORD-Eintrag
ord-9a5c7a12461a462ca56932389872f23b
Quelldatensatz
uspto-grants-1978_09
Patentnummer
US04113464

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