5-Chloro-2-methoxybenzoyl chloride → alpha,alpha-Dimethyl-beta-{4-[2-(5-chloro-2-methoxybenzamido)-ethyl]-phenyl}-propionic acid
Reaktionsgleichung
Cl.[CH3:2][C:3]([CH3:19])([CH2:9][C:10]1[CH:15]=[CH:14][C:13]([CH2:16][CH2:17][NH2:18])=[CH:12][CH:11]=1)[C:4]([O:6]CC)=[O:5].[Cl:20][C:21]1[CH:22]=[CH:23][C:24]([O:30][CH3:31])=[C:25]([CH:29]=1)[C:26](Cl)=[O:27]>>[CH3:19][C:3]([CH3:2])([CH2:9][C:10]1[CH:11]=[CH:12][C:13]([CH2:16][CH2:17][NH:18][C:26](=[O:27])[C:25]2[CH:29]=[C:21]([Cl:20])[CH:22]=[CH:23][C:24]=2[O:30][CH3:31])=[CH:14][CH:15]=1)[C:4]([OH:6])=[O:5]Komponenten
3
Versuchsvorschrift
By the reaction of ethyl α,α-dimethyl-β-[4-(2-aminoethyl)-phenyl]-propionate hydrochloride with 5-chloro-2-methoxybenzoyl chloride, there is obtained α,α-dimethyl-β-{4-[2-(5-chloro-2-methoxybenzamido)-ethyl]-phenyl}-propionic acid; m.p. 138°-141° C., after recrystallization from ethyl acetate.
Quellen und Nachweise
- ORD-Eintrag
- ord-e5a380b5576345bdbf6819659eb89504