1-Methylpiperazine → HCID 47864, Verbindung

HRID 1763952Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1763952
[C:1]([NH:4][C:5]1[C:6]([O:18][CH2:19][CH2:20]Cl)=[C:7]([O:16][CH3:17])[C:8]2[O:12][CH:11]=[CH:10][C:9]=2[C:13]=1[O:14][CH3:15])(=[O:3])[CH3:2].[CH3:22][N:23]1[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]1>C1(C)C=CC=CC=1>[C:1]([NH:4][C:5]1[C:6]([O:18][CH2:19][CH2:20][N:26]2[CH2:27][CH2:28][N:23]([CH3:22])[CH2:24][CH2:25]2)=[C:7]([O:16][CH3:17])[C:8]2[O:12][CH:11]=[CH:10][C:9]=2[C:13]=1[O:14][CH3:15])(=[O:3])[CH3:2]

Komponenten

4

Edukt 2

HCID 531671-MethylpiperazineHCID 12672371HCID 12672371, Verbindung

Produkt 1

HCID 47864HCID 47864, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Versuchsvorschrift

A solution of 15.5 g (0.05 mole) of 5-acetamido 6-(2-chloro ethoxy) 4,7 dimethoxy benzofuran prepared in the preceding example and 15 g (0.15 mole) of N-methyl piperazine was brought to reflux for 8 hours in 100 ml of toluene. It was filtered and the filtrate evaporated under vacum the residue was taken up again in alcohol and hydrochloric alcohol was added. It was filtered and recrystallized in absolute alcohol.

Aufarbeitung

  1. filtrationIt was filtered
  2. customthe filtrate evaporated under vacum the residue
  3. additionhydrochloric alcohol was added
  4. filtrationIt was filtered
  5. customrecrystallized in absolute alcohol

Quellen und Nachweise

ORD-Eintrag
ord-73ae93da663f4046b3e7c6e1692248ec
Quelldatensatz
uspto-grants-1978_09
Patentnummer
US04113951

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