1H-imidazole-2-carbaldehyde → HCID 23346561, Verbindung

HRID 1764045Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1764045
[CH3:1][CH:2]1[CH2:6][CH2:5][C:4]2([C:11]([CH3:13])([CH3:12])[CH2:10][CH2:9][CH2:8][C:7]2([CH3:15])[OH:14])[O:3]1.[CH:16](C1NC=CN=1)=[O:17]>>[CH:16]([O:14][C:7]1([CH3:15])[CH2:8][CH2:9][CH2:10][C:11]([CH3:13])([CH3:12])[C:4]21[O:3][CH:2]([CH3:1])[CH2:6][CH2:5]2)=[O:17]

Komponenten

3

Edukt 2

HCID 249551H-imidazole-2-carbaldehydeHCID 654286-Hydroxydihydrotheaspirane

Produkt 1

HCID 23346561HCID 23346561, Verbindung

Versuchsvorschrift

0.4 g (0.002 M) of 2,6,10,10-tetramethyl-1-oxa-spiro[4.5]decan-6-ol -- isomer A; see Example 1 -- were intimately mixed with 0.5 g (0.005 M) of freshly sublimated formylimidazole and then kept for 2 days at room temperature. The reaction mixture was then extracted with ether and the organic layer washed, dried, evaporated and finally subjected to a fractional distillation to give 0.3 g of a product having b.p. 70°-80°/0.5 Torr and containing 60% of the desired ester. An analytical sample was purified by vapour phase chromatography.

Aufarbeitung

  1. extractionThe reaction mixture was then extracted with ether
  2. washthe organic layer washed
  3. customdried
  4. customevaporated
  5. distillationfinally subjected to a fractional distillation

Quellen und Nachweise

ORD-Eintrag
ord-aac398c990874d629dd797e75c4f54eb
Quelldatensatz
uspto-grants-1978_09
Patentnummer
US04114630

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