Dimethylamine → 4-Dimethylamino-1,3-dimethyl-6-phenyl-1H-pyrazolo[3,4-b]pyridine

HRID 1764096Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1764096
Cl[C:2]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[N:5]=[C:4]2[N:14]([CH3:18])[N:15]=[C:16]([CH3:17])[C:3]=12.[CH3:19][NH:20][CH3:21]>>[CH3:19][N:20]([CH3:21])[C:2]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[N:5]=[C:4]2[N:14]([CH3:18])[N:15]=[C:16]([CH3:17])[C:3]=12

Komponenten

3

Edukt 2

HCID 674DimethylamineHCID 227705064-chloro-1,3-dimethyl-6-phenyl-1H-pyrazolo[3,4-b]pyridine

Produkt 1

HCID 227704984-Dimethylamino-1,3-dimethyl-6-phenyl-1H-pyrazolo[3,4-b]pyridine

Versuchsvorschrift

15.5 gms. of 4-chloro-1,3-dimethyl-6-phenyl-1H-pyrazolo[3,4-b]pyridine (0.06 mol.) are added to 132 ml. of a solution of dimethylamine (40%). The reaction mixture is heated at 190°-200° C. for 16 hours in an autoclave and after cooling to room temperature is evaporated in vacuo. The residue is treated with water and extracted with ether. After evaporation of the extract, the 4-dimethylamino-1,3-dimethyl-6-phenyl-1H-pyrazolo[3,4-b]pyridine (15.6 gms. = 98%) is recrystallized from ligroin, m.p. 90°-91° C.

Aufarbeitung

  1. temperatureThe reaction mixture is heated at 190°-200° C. for 16 hours in an autoclave
  2. customis evaporated in vacuo
  3. additionThe residue is treated with water
  4. extractionextracted with ether
  5. customAfter evaporation of the extract
  6. customthe 4-dimethylamino-1,3-dimethyl-6-phenyl-1H-pyrazolo[3,4-b]pyridine (15.6 gms. = 98%) is recrystallized from ligroin, m.p. 90°-91° C.

Quellen und Nachweise

ORD-Eintrag
ord-4264836c56804627b9e7643e4485dd31
Quelldatensatz
uspto-grants-1978_09
Patentnummer
US04115394

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