Reaktionsgleichung
[Na].[C:2]1([C:8]2[CH:13]=[CH:12][C:11]([OH:14])=[CH:10][CH:9]=2)[CH2:7][CH2:6][CH2:5][CH2:4][CH:3]=1.[CH2:15]([O:17][C:18](=[O:28])[CH:19](Br)[CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH3:26])[CH3:16]>C(O)C>[CH2:15]([O:17][C:18](=[O:28])[CH:19]([O:14][C:11]1[CH:10]=[CH:9][C:8]([CH:2]2[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]2)=[CH:13][CH:12]=1)[CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH3:26])[CH3:16]Komponenten
5
Edukt 3
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
To a solution of 2.4 g of sodium in 100 ml of absolute ethanol are added initially 15 g of p-(1-cyclohexenyl)-phenol in a small amount of absolute ethanol at room temperature under anhydrous conditions and with stirring. 34 Grams of α-bromo-nonanoic acid ethyl ester are then added dropwise and the reaction mixture is stirred for 24 hours at 50° C. The ethanol is subsequently stripped off in vacuo and the residue is partitioned between water and ice-cold N sodium hydroxide solution. The organic phase is washed until neutral, dried over sodium sulphate and concentrated in vacuo. The residue yields the crude α-[p-(1-cyclohexyl)-phenoxy]-nonanoic acid ethyl ester of the formula ##STR15## in the form of an oil.
Aufarbeitung
- stirringthe reaction mixture is stirred for 24 hours at 50° C
- customthe residue is partitioned between water and ice-cold N sodium hydroxide solution
- washThe organic phase is washed until neutral,
- dry with materialdried over sodium sulphate
- concentrationconcentrated in vacuo
Quellen und Nachweise
- ORD-Eintrag
- ord-b135ba77b3ca44ea8d9fb59e182d5601
- Quelldatensatz
- uspto-grants-1978_09
- Patentnummer
- US04115416
Verknüpfte Notizen
Wird geladen…