2-Methylbenzenesulfonic acid → HCID 22768127, Verbindung

HRID 1764415Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1764415
[CH:1]([N:4]([CH2:9][CH:10]([O:14]CC)[O:11][CH2:12]C)[C:5](=[O:8])[CH2:6][Cl:7])([CH3:3])[CH3:2].[C:17]1([CH3:27])[C:18](S(O)(=O)=O)=CC=C[CH:22]=1.C(=O)([O-])[O-].[Na+].[Na+]>C(O)C>[CH:1]([N:4]([CH2:9][CH:10]1[O:14][CH2:22][C:17]([CH3:18])([CH3:27])[CH2:12][O:11]1)[C:5](=[O:8])[CH2:6][Cl:7])([CH3:3])[CH3:2]

Komponenten

5

Edukt 3

HCID 69252-Methylbenzenesulfonic acidHCID 10340Sodium CarbonateHCID 22768137HCID 22768137, Verbindung

Produkt 1

HCID 22768127HCID 22768127, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

N-Isopropyl-N-(2,2-diethoxyethyl)-α-chloroacetamide (10 grams), 2,2-dimethylpropandiol-1,3 (4.1 grams) and trace amounts of toluenesulfonic acid were charged into a glass reaction vessel equipped with a mechanical stirrer, thermometer and reflux condenser. The reaction mixture was heated until no more ethanol was given off. After this time sodium carbonate (1 gram) was added to the mixture with stirring and the resulting mixture was distilled to yield the desired product N-isopropyl-N-(5,5-dimethyl-1,3-dioxan-2-ylmethyl)-α-chloroacetamide having a boiling point of 175° C. at 1 mm of Hg pressure.

Aufarbeitung

  1. additionwere charged into a glass reaction vessel
  2. customequipped with a mechanical stirrer
  3. temperaturethermometer and reflux condenser
  4. distillationthe resulting mixture was distilled

Quellen und Nachweise

ORD-Eintrag
ord-94a5ad17770a463c9e31ecf3e4b2b2ef
Quelldatensatz
uspto-grants-1978_09
Patentnummer
US04116670

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