Hydrazinecarboxaldehyde → 6-(p-Bromophenyl)-1,2,4-triazolo[4,3-b]pyridazine

HRID 1764637

Reaktionsgleichung

Reaktionsgleichung von HRID 1764637
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]=[N:10][C:11](Cl)=[CH:12][CH:13]=2)=[CH:4][CH:3]=1.[CH:15]([NH:17][NH2:18])=O>C(O)CCC>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]3[N:10]([CH:15]=[N:17][N:18]=3)[N:9]=2)=[CH:4][CH:3]=1

Komponenten

4

Edukt 2

HCID 12229HydrazinecarboxaldehydeHCID 64052553-(4-Bromophenyl)-6-chloropyridazine

Produkt 1

HCID 227689336-(p-Bromophenyl)-1,2,4-triazolo[4,3-b]pyridazine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 2631-ButanolLösungsmittel

Versuchsvorschrift

A mixture of 3.76 g. of 3-(p-bromophenyl)-6-chloropyridazine, 1.80 g. of formylhydrazine and 50 ml. of butyl alcohol is heated to reflux and allowed to reflux overnight. The reaction mixture is allowed to cool and the precipitated product is washed with water, air dried and recrystallized from methyl alcohol, m.p. 209°-211° C.

Aufarbeitung

  1. additionA mixture of 3.76 g
  2. temperatureto reflux
  3. temperatureto reflux overnight
  4. temperatureto cool
  5. washthe precipitated product is washed with water, air
  6. customdried
  7. customrecrystallized from methyl alcohol, m.p. 209°-211° C.

Quellen und Nachweise

ORD-Eintrag
ord-75431e61e93e4b2a95d18a4233c3c94c
Quelldatensatz
uspto-grants-1978_09
Patentnummer
US04117130

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