5-Methoxy-o-toluidine → 4-(5-Methoxy-2-methylanilino)-6-(methoxymethyl)-2-(2-methyl-1,3-thiazol-4-yl)pyrimidine

HRID 1765157

Reaktionsgleichung

Reaktionsgleichung von HRID 1765157
Cl[C:2]1[CH:7]=[C:6]([CH2:8][O:9][CH3:10])[N:5]=[C:4]([C:11]2[N:12]=[C:13]([CH3:16])[S:14][CH:15]=2)[N:3]=1.[CH3:17][O:18][C:19]1[CH:20]=[CH:21][C:22]([CH3:26])=[C:23]([CH:25]=1)[NH2:24]>>[CH3:17][O:18][C:19]1[CH:20]=[CH:21][C:22]([CH3:26])=[C:23]([CH:25]=1)[NH:24][C:2]1[CH:7]=[C:6]([CH2:8][O:9][CH3:10])[N:5]=[C:4]([C:11]2[N:12]=[C:13]([CH3:16])[S:14][CH:15]=2)[N:3]=1

Komponenten

3

Edukt 2

HCID 995005-Methoxy-o-toluidineHCID 27995334-Chloro-6-(methoxymethyl)-2-(2-methyl-1,3-thiazol-4-yl)pyrimidine

Produkt 1

HCID 99467624-(5-Methoxy-2-methylanilino)-6-(methoxymethyl)-2-(2-methyl-1,3-thiazol-4-yl)pyrimidine

Versuchsvorschrift

The title compound was prepared from a mixture of 4-chloro-6-(methoxymethyl)-2-(2-methyl-1,3-thiazol-4-yl)pyrimidine (50 mg, 0.196 mmol) and 5-methoxy-2-methylaniline (27 mg, 0.196 mmol) similar to Example 13 and isolated as a tan oil (42 mg, 60%). 1H NMR (CDCl3): 8.12 (s, 1H), 7.19 (d, J=8.4 Hz, 1H), 6.99 (d, J=2.4 Hz, 1H), 6.89 (s, 1H), 6.75 (dd, J=3.0, 8.7 Hz, 1H), 6.56 (s, 1H), 4.50 (s, 2H), 3.80 (s, 3H), 3.44 (s, 3H), 2.83 (s, 3H), 2.21 (s, 3H).

Quellen und Nachweise

ORD-Eintrag
ord-bb38d9642a28473ca85c367fd8b02935
Quelldatensatz
uspto-grants-2007_06
Patentnummer
US07226927B2

Verknüpfte Notizen

Wird geladen…