Hydrochloric Acid → 5-Amino-1-(2-hydroxyethyl)-4-nitrosopyrazole hydrochloride

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

To a flask having an inner volume of 25 ml and equipped with a stirring device, a thermometer and a reflux condenser were charged 3.37 g (22 mmol) of 3,3-dimethoxy-2-hydroxyiminopropionitrile with a purity of 94.0% by weight synthesized in the same manner as in Example 1, 1.60 g (20 mmol) of 2-hydroxyethylhydrazine with a purity of 95% by weight, 9.6 ml of isopropyl alcohol and 2 ml (24 mmol) of conc. hydrochloric acid, and the mixture was reacted under reflux (79 to 80° C.) for one hour. After completion of the reaction, when the reaction mixture was analyzed by high performance liquid chromatography (absolute calibration curve method), it was found that 3.35 g of 5-amino-1-(2-hydroxyethyl)-4-nitrosopyrazole hydrochloride (Reaction yield: 86.9%) had been formed.

Herkunft & Nachweise