2-Amino-5-chlorobenzophenone → 3-[4-(2-Benzoyl-4-chloro-phenylsulfamoyl)-phenyl]propionic acid methyl ester

HRID 1765514

Reaktionsgleichung

Reaktionsgleichung von HRID 1765514
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][C:3]=1[C:9]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)=[O:10].[CH3:17][O:18][C:19](=[O:32])[CH2:20][CH2:21][C:22]1[CH:27]=[CH:26][C:25]([S:28](Cl)(=[O:30])=[O:29])=[CH:24][CH:23]=1>>[CH3:17][O:18][C:19](=[O:32])[CH2:20][CH2:21][C:22]1[CH:27]=[CH:26][C:25]([S:28](=[O:29])(=[O:30])[NH:1][C:2]2[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][C:3]=2[C:9](=[O:10])[C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=2)=[CH:24][CH:23]=1

Komponenten

3

Edukt 2

HCID 128702-Amino-5-chlorobenzophenoneHCID 23158517Methyl 3-[4-(chlorosulfonyl)phenyl]propanoate

Produkt 1

HCID 117514873-[4-(2-Benzoyl-4-chloro-phenylsulfamoyl)-phenyl]propionic acid methyl ester

Versuchsvorschrift

The title compound was prepared according to the general procedure for the synthesis of N-Aryl-benzenesulfonamides previously described using 116 mg of (2-Amino-5-chloro-phenyl)-phenyl-methanone and 131 mg of 3-(4-chlorosulfonyl-phenyl)-propionic acid methyl ester. 1H-NMR (400 MHz, CDCl3): δ 2.50 (t, 2H, J=8.0 Hz), 2.83 (t, 2H, J=8.0 Hz), 3.64 (s, 3H), 7.08 (d, 2H, J=8.8 Hz), 7.33 (d, 1H, J=2.8 Hz), 7.36–7.42 (m, 4H), 7.47 (dd, 1H, J=8.8 Hz, 2.8 Hz), 7.58 (m, 3H), 7.75 (d, 1H, J=8.8 Hz), 9.78 (s, 1H). MS: m/z 458.9 (M++1).

Quellen und Nachweise

ORD-Eintrag
ord-6d434b3b24924a4584e58d9fc0798148
Quelldatensatz
uspto-grants-2007_06
Patentnummer
US07227035B2

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