Methanol → 6-Ethynyl-8-hydroxy-2,2,4,4-tetramethyl-chroman

HRID 1765724Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1765724
Br[C:2]1[CH:3]=[C:4]2[C:9](=[C:10](C#C[Si](C)(C)C)[CH:11]=1)[O:8][C:7]([CH3:19])([CH3:18])[CH2:6][C:5]2([CH3:21])[CH3:20].[C:22](=[O:25])([O-])[O-].[K+].[K+].[CH3:28]O>>[C:11]([C:2]1[CH:3]=[C:4]2[C:9](=[C:22]([OH:25])[CH:28]=1)[O:8][C:7]([CH3:18])([CH3:19])[CH2:6][C:5]2([CH3:20])[CH3:21])#[CH:10]

Komponenten

4

Edukt 3

HCID 887MethanolHCID 11430Potassium CarbonateHCID 574242166-Bromo-8-trimethylsilanylethynyl-2,2,4,4-tetramethyl chroman2×

Produkt 1

HCID 211072286-Ethynyl-8-hydroxy-2,2,4,4-tetramethyl-chroman

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

A solution of 6-bromo-8-trimethylsilanylethynyl-2,2,4,4-tetramethyl chroman (Intermediate 18, 0.47 g, 1.56 mmol) in methanol (5 mL) was treated with potassium carbonate (0.2 g, 1.45 mmol) and the resulting reaction mixture was heated at 80° C. for 3 h. The solvent was evaporated in vacuo, the residue was diluted with water and extracted with ethyl acetate.

Aufarbeitung

  1. customthe resulting reaction mixture
  2. customThe solvent was evaporated in vacuo
  3. additionthe residue was diluted with water
  4. extractionextracted with ethyl acetate

Quellen und Nachweise

ORD-Eintrag
ord-43f7f5d27c544b728939541501aaae8a
Quelldatensatz
uspto-grants-2007_06
Patentnummer
US07226951B2

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