1-(Diphenylmethyl)-3-[(2-nitrophenylmethyl)amino]-azetidine → 3-[(2-Aminophenylmethyl)amino]-1-(diphenylmethyl)-azetidine

HRID 1766182Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1766182
[C:1]1([CH:7]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[N:8]2[CH2:11][CH:10]([NH:12][CH2:13][C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=3[N+:20]([O-])=O)[CH2:9]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>CO.[Rh].C>[NH2:20][C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=1[CH2:13][NH:12][CH:10]1[CH2:9][N:8]([CH:7]([C:23]2[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=2)[C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[CH2:11]1

Komponenten

4

Edukt 1

HCID 211099031-(Diphenylmethyl)-3-[(2-nitrophenylmethyl)amino]-azetidine

Produkt 1

HCID 211099093-[(2-Aminophenylmethyl)amino]-1-(diphenylmethyl)-azetidine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 10080373Rhodium carbonKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

A solution of 20.0 g (0.5355 mol) of 1-(diphenylmethyl)-3-[(2-nitrophenylmethyl)amino]-azetidine in 200 ml of methanol was hydrogenated in the presence of 4 g of 5% rhodium/charcoal for 5 hours at ambient temperature. The catalyst was filtered off, the filtrate was concentrated by evaporation in vacuo. 17.7 g (96% of theoretical) of a colourless, highly viscous oil were obtained, which was further processed without any additional purification.

Aufarbeitung

  1. filtrationThe catalyst was filtered off
  2. concentrationthe filtrate was concentrated by evaporation in vacuo
  3. custom17.7 g (96% of theoretical) of a colourless, highly viscous oil were obtained
  4. customwhich was further processed without any additional purification

Quellen und Nachweise

ORD-Eintrag
ord-734891da2bc948f3b1ba69c827e3506a
Quelldatensatz
uspto-grants-2007_06
Patentnummer
US07230001B1

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