Cyclopropanemethanol → 6-cyclopropylmethoxy-5-(4-fluoro-phenyl)-N-(1-hydroxy-cyclopentylmethyl)-nicotinamide

HRID 1766554

Reaktionsgleichung

Reaktionsgleichung von HRID 1766554
Br[C:2]1[CH:3]=[C:4]([C:9]([OH:11])=O)[CH:5]=[N:6][C:7]=1Cl.[OH:12][CH2:13][CH:14]1[CH2:16][CH2:15]1.[F:17][C:18]1[CH:23]=[CH:22][C:21](B(O)O)=[CH:20][CH:19]=1.Cl.[NH2:28][CH2:29][C:30]1([OH:35])[CH2:34][CH2:33][CH2:32][CH2:31]1>>[CH:14]1([CH2:13][O:12][C:7]2[C:2]([C:21]3[CH:22]=[CH:23][C:18]([F:17])=[CH:19][CH:20]=3)=[CH:3][C:4]([C:9]([NH:28][CH2:29][C:30]3([OH:35])[CH2:34][CH2:33][CH2:32][CH2:31]3)=[O:11])=[CH:5][N:6]=2)[CH2:16][CH2:15]1

Komponenten

5

Edukt 4

HCID 75644CyclopropanemethanolHCID 2854335-Bromo-6-chloropyridine-3-carboxylic acidHCID 2856454-Fluorophenylboronic acidHCID 211096931-(Aminomethyl)cyclopentan-1-ol--hydrogen chloride (1/1)

Produkt 1

HCID 670127846-cyclopropylmethoxy-5-(4-fluoro-phenyl)-N-(1-hydroxy-cyclopentylmethyl)-nicotinamide

Versuchsvorschrift

The title compound was synthesized in analogy to Example 75, using 5-bromo-6-chloro-3-pyridinecarboxylic acid, hydroxymethyl-cyclopropan, 4-fluorophenylboronic acid and 1-aminomethyl-cyclopentanol hydrochloride (CAS [76066-27-8]) as starting materials to yield 6-cyclopropylmethoxy-5-(4-fluoro-phenyl)-N-(1-hydroxy-cyclopentylmethyl)-nicotinamide. MS (ISP) 385.3 (M+H)+.

Aufarbeitung

  1. customThe title compound was synthesized in analogy to Example 75

Quellen und Nachweise

ORD-Eintrag
ord-871e7b07416649d5a4cece42dc05d711
Quelldatensatz
uspto-grants-2007_06
Patentnummer
US07229999B2

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