Methanol → 4(1H)-Quinazolinone

HRID 1767149Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1767149
[C:1]([O-:10])(=O)[C:2]1[C:3](=[CH:5][CH:6]=[CH:7][CH:8]=1)[NH2:4].[NH4+:11].C([O-])([O-])OC.[CH3:17]O>>[N:4]1[C:3]2[C:2](=[CH:8][CH:7]=[CH:6][CH:5]=2)[C:1](=[O:10])[NH:11][CH:17]=1

Komponenten

4

Edukt 3

HCID 887MethanolHCID 53629101MethylorthoformateHCID 6736264670346-37-1

Produkt 1

HCID 1354087534(1H)-QuinazolinoneAusbeute 81 %

Versuchsvorschrift

In a 2-mL volume stainless steel pressure-resistant vessel were placed 280 mg (1.8 mmol) of ammonium anthranilate (prepared in the same manner as in Reference Example 1), 400 mg (3.6 mmol) of methyl orthoformate, and 1.5 mL of methanol. The reaction was carried out at 120° C. for 2 hours. After the reaction was complete, the reaction mixture was cooled to room temperature and analyzed (according to absolute quantitative analysis) by high performance liquid chromatography. There was produced 214 mg (reaction yield: 81%) of quinazolin-4-one.

Aufarbeitung

  1. customIn a 2-mL volume stainless steel pressure-resistant vessel were placed

Quellen und Nachweise

ORD-Eintrag
ord-b2e795dc31064a299c1d4592b82795e1
Quelldatensatz
uspto-grants-2007_06
Patentnummer
US07232903B2

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