Ethanol → Ethyl 3-bromo-5-methylbenzoate

HRID 1767242

Reaktionsgleichung

Reaktionsgleichung von HRID 1767242
[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([CH3:11])[CH:10]=1)[C:5]([OH:7])=[O:6].[CH2:12](O)[CH3:13]>S(=O)(=O)(O)O.C(OCC)C.O>[CH2:12]([O:6][C:5](=[O:7])[C:4]1[CH:8]=[C:9]([CH3:11])[CH:10]=[C:2]([Br:1])[CH:3]=1)[CH3:13]

Komponenten

5

Edukt 2

HCID 702EthanolHCID 34331273-Bromo-5-methylbenzoic acid

Produkt 1

HCID 20086624Ethyl 3-bromo-5-methylbenzoateAusbeute 94 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 1118Sulfuric AcidKatalysatorHCID 21584184Diethylether waterLösungsmittel

Reaktionsbedingungen

Temperatur
90 °C

Versuchsvorschrift

Sulphuric acid (10 drops) was added to 3-bromo-5-methylbenzoic acid (1.18 g, 5.49 mmol) in ethanol (20 ml) and refluxed at 90° C. for 20 hours. After cooling, the mixture was diluted with diethyl ether/water and the organic phase washed with sodium hydrogen bicarbonate (saturated solution), dried (magnesium sulphate) and evaporated to dryness to give the title compound as a pale yellow oil (1.249 g, 94%).

Aufarbeitung

  1. temperatureAfter cooling
  2. washthe organic phase washed with sodium hydrogen bicarbonate (saturated solution)
  3. dry with materialdried (magnesium sulphate)
  4. customevaporated to dryness

Quellen und Nachweise

ORD-Eintrag
ord-f743fbd499fe4d2e9d01a567776bde30
Quelldatensatz
uspto-grants-2007_06
Patentnummer
US07232821B2

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