Piperazine, 1-(1-adamantyl)- → 1-(1-Adamantyl)-4-amidinopiperazine hydroiodide

HRID 1768962

Reaktionsgleichung

Reaktionsgleichung von HRID 1768962
C(N1CCNCC1)=O.[C:9]12([N:19]3[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]3)[CH2:18][CH:13]3[CH2:14][CH:15]([CH2:17][CH:11]([CH2:12]3)[CH2:10]1)[CH2:16]2.[IH:25].CS[C:28](=[NH:30])[NH2:29]>>[IH:25].[C:9]12([N:19]3[CH2:24][CH2:23][N:22]([C:28](=[NH:29])[NH2:30])[CH2:21][CH2:20]3)[CH2:16][CH:15]3[CH2:14][CH:13]([CH2:12][CH:11]([CH2:17]3)[CH2:10]1)[CH2:18]2

Komponenten

4

Edukt 3

HCID 35373Piperazine, 1-(1-adamantyl)-HCID 821911-PiperazinecarboxaldehydeHCID 197812S-methylthiouronium iodide

Produkt 1

HCID 189462951-(1-Adamantyl)-4-amidinopiperazine hydroiodideAusbeute 72,3 %

Versuchsvorschrift

The title compound was prepared as described for 1-formylpiperazine in Example 1 of the published European patent application No. 39,190, starting with 1-(1-adamantyl)piperazine and S-methyl-isothiourea hydroiodide, mp. 278°-280° C., yield: 72.3 %.

Quellen und Nachweise

ORD-Eintrag
ord-73472acde6f74bd990200d27ffc51b80
Quelldatensatz
uspto-grants-1995_01
Patentnummer
US05380724

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