2-(N-Benzyl-N-methylamino)-1-(N-piperidinyl)ethane → Methyl(2-(piperidin-1-yl)ethyl)amine

HRID 1770093

Reaktionsgleichung

Reaktionsgleichung von HRID 1770093
[CH2:1]([N:8]([CH2:10][CH2:11][N:12]1[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1)C)C1C=CC=CC=1>CCO.[OH-].[OH-].[Pd+2]>[CH3:1][NH:8][CH2:10][CH2:11][N:12]1[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1

Komponenten

4

Edukt 1

HCID 232084362-(N-Benzyl-N-methylamino)-1-(N-piperidinyl)ethane

Produkt 1

HCID 3157473Methyl(2-(piperidin-1-yl)ethyl)amine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 9942167Palladium hydroxideKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

A solution of the title compound of Step 11 (1.85 g, 7.96mmol) and 20% Pd(OH)2 on carbon in EtOH (50 mL) was placed under a hydrogen atmosphere (60 psi) at room temperature for 17 hours. The mixture was filtered and concentrated to give the title compound as a clear, yellow liquid (1.02 g, 90% crude yield). The proton spectral data were consistent with the proposed structure.

Aufarbeitung

  1. customat room temperature
  2. customfor 17 hours
  3. filtrationThe mixture was filtered
  4. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-db658deda78e43e09f66a70eb246ea1b
Quelldatensatz
uspto-grants-1995_01
Patentnummer
US05385898

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