Aniline → HCID 15022346, Verbindung

HRID 1770320Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1770320
[Cl:1][C:2]1[C:3]([C:7](Cl)=[O:8])=[CH:4][S:5][CH:6]=1.[NH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>O1CCOCC1.N1C=CC=CC=1>[Cl:1][C:2]1[C:3]([C:7]([NH:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[O:8])=[CH:4][S:5][CH:6]=1

Komponenten

5

Edukt 2

HCID 6115AnilineHCID 129147964-Chlorothiophene-3-carbonyl chloride

Produkt 1

HCID 15022346HCID 15022346, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 1049PyridineLösungsmittelHCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

4-Chlorothiophene-3-carbonyl chloride (13.5 g, 0.075 mol) are dissolved in 30 ml of dioxane and the solution is added dropwise at room temperature to a solution of aniline (7.7 g, 0.083 mol) in pyridine (160 ml). Stirring is carried out for 12 hours at room temperature, after which the mixture is evaporated to dryness and the residue is taken up in dichloromethane. The organic phase is extracted with aqueous citric acid solution, sodium bicarbonate solution and water, dried and evaporated to dryness. Yield: 16.7 g, 94%; mp. 119° to 121° C.

Aufarbeitung

  1. customafter which the mixture is evaporated to dryness
  2. extractionThe organic phase is extracted with aqueous citric acid solution, sodium bicarbonate solution and water
  3. customdried
  4. customevaporated to dryness

Quellen und Nachweise

ORD-Eintrag
ord-d6e97c5bb61e42c1a2ac2eb24abb4254
Quelldatensatz
uspto-grants-1995_01
Patentnummer
US05386036

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