Cyclopropanecarbonitrile → 1-(4-Bromo-2-iodobenzyl)cyclopropanecarbonitrile

Beteiligte Stoffe

Reaktionsschritte

The title compound (2.1 g, 55% yield) was prepared as described for 1-(4-Bromo-2-iodobenzyl)cyclobutanecarbonitrile (Intermediate 37) starting from cyclopropanecarbonitrile (1.96 mL, 26.6 mmol) and 4-bromo-1-(bromomethyl)-2-iodobenzene (see Caruso, A; Tovar, J., D. J. Org. Chem. 2011, 76, 2227-2239) (4.0 g, 10.6 mmol): 1H NMR (400 MHz, CDCl3) δ ppm 1.02-1.07 (m, 2H), 1.33-1.37 (m, 2H), 2.98 (s, 2H), 7.35 (d, 1H), 7.51 (dd, 1H), 8.02 (d, 1H); MS (CI) m/z 362 [M+H]+.

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