Benzyl Alcohol → Benzyl 2-bromo-2,2-difluoroacetate

HRID 1771028Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1771028
[Br:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[CH2:8](O)[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.O.C1(C)C=CC(S(O)(=O)=O)=CC=1>C1CCCCC1>[Br:1][C:2]([F:7])([F:6])[C:3]([O:5][CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)=[O:4]

Komponenten

5

Edukt 3

HCID 244Benzyl AlcoholHCID 521998p-Toluenesulfonic acid monohydrateHCID 27732822-Bromo-2,2-difluoroacetic acid

Produkt 1

HCID 10378165Benzyl 2-bromo-2,2-difluoroacetate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8078CyclohexaneLösungsmittel

Versuchsvorschrift

This compound was prepared according to Example 2a from bromodifluoroacetic acid (9.82 g; 68.7 mmol), benzyl alcohol (7.0 g; 65 mmol), and p-toluenesulphonic acid monohydrate (50 mg) in cyclohexane (120 mL). The crude product obtained after evaporation was used as is without any further workup in 3b.

Aufarbeitung

  1. customThis compound was prepared

Quellen und Nachweise

ORD-Eintrag
ord-73f25d56bc8441348449fcc0b66adb7e
Quelldatensatz
uspto-grants-2016_02
Patentnummer
US09249086B2

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