Acrylonitrile → 1-(Pyridin-3-yl)-4,5-dihydro-1H-pyrazol-3-amine
Reaktionsgleichung
[C:1](#[N:4])[CH:2]=[CH2:3].[NH:5]([C:7]1[CH:8]=[N:9][CH:10]=[CH:11][CH:12]=1)[NH2:6]>>[N:9]1[CH:10]=[CH:11][CH:12]=[C:7]([N:5]2[CH2:3][CH2:2][C:1]([NH2:4])=[N:6]2)[CH:8]=1Komponenten
3
Versuchsvorschrift
In a typical reaction, 3-hydrazinopyridine•dihydrochloride and an anhydrous alcohol are introduced into a reaction vessel and the alkoxide base is gradually added. The mixture is stirred and the acrylonitrile is added. The mixture is stirred at about 60° C. until most of the 3-hydrazinopyridine has reacted. The mixture is allowed to cool and the excess base is neutralized with acid. The crude 1-(pyridin-3-yl)-4,5-dihydro-1H-pyrazol-3-amine (9a) is conveniently isolated and purified by standard techniques.
Aufarbeitung
- customhas reacted
- temperatureto cool