HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 1772025Erstellt: 27. Oktober 2026
1,7-Naphthyridin-8-amine → 8-imino-1,7-naphthyridin-7(8H)-amine 2,4,6-trimethylbenzenesulfonate
https://huagongshe.com/reaction/1772025
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | 1,7-Naphthyridin-8-amine | HCID 2737037 | — |
| Edukt | O-(2,4,6-Trimethylbenzenesulfonyl)hydroxylamine | HCID 11830845 | — |
| Lösungsmittel | Dichloromethane | HCID 6344 | — |
| Produkt | 8-imino-1,7-naphthyridin-7(8H)-amine 2,4,6-trimethylbenzenesulfonate | HCID 86667814 | 80,8% |
Reaktionsschritte
To a solution of 1,7-naphthyridin-8-amine (600 mg, 4.13 mmol) in DCM (5 mL) was added a solution of O-(mesitylsulfonyl)hydroxylamine (2.7 g, 12.4 mmol) in DCM (10 mL) at 0° C. The mixture was stirred at 0° C. for 2 h. The precipitate was filtered and collected to give 8-imino-1,7-naphthyridin-7(8H)-amine-2,4,6-trimethylbenzenesulfonate as a brown solid (1.2 g, yield 67%). ESI MS: m/z 161.1 [M+H]+.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patentnummer | US09249162B2 |
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| Quelldatensatz | uspto-grants-2016_02 |
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| ORD ID | ord-1d46f4df65e6431c9f0ff6094791ee48 |
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| Quellennotiz | uspto-grants-2016_02 |
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