Boron tribromide → 4-(2-Chloro-6-fluorobenzyl)-2-(4-hydroxy-3,5-di methyl phenyl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide

HRID 1772956Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1772956
[Cl:1][C:2]1[CH:31]=[CH:30][CH:29]=[C:28]([F:32])[C:3]=1[CH2:4][N:5]1[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=2[S:8](=[O:16])(=[O:15])[N:7]([C:17]2[CH:22]=[C:21]([CH3:23])[C:20]([O:24]C)=[C:19]([CH3:26])[CH:18]=2)[C:6]1=[O:27].B(Br)(Br)Br.OC1C(C)=CC(N2C(=O)N(CC3C(F)=CC(F)=CC=3F)C3C=CC=CC=3S2(=O)=O)=CC=1C>>[Cl:1][C:2]1[CH:31]=[CH:30][CH:29]=[C:28]([F:32])[C:3]=1[CH2:4][N:5]1[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=2[S:8](=[O:15])(=[O:16])[N:7]([C:17]2[CH:18]=[C:19]([CH3:26])[C:20]([OH:24])=[C:21]([CH3:23])[CH:22]=2)[C:6]1=[O:27]

Komponenten

4

Edukt 3

HCID 25134Boron tribromideHCID 727212754-(2-Chloro-6-fluorobenzyl)-2-(4-methoxy-3,5-dimethylphenyl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxideHCID 727218952-(4-Hydroxy-3,5-dimethylphenyl)-4-(2,4,6-trifluorobenzyl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide

Produkt 1

HCID 727219884-(2-Chloro-6-fluorobenzyl)-2-(4-hydroxy-3,5-di methyl phenyl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxideAusbeute 54,2 %

Versuchsvorschrift

The title compound (0.12 g, 0.26 mmol) was prepared from (81) (0.23 g, 0.48 mmol) and boron tribromide (1.0M solution in DCM, 0.60 mL, 0.60 mmol) using the methods of (114).

Quellen und Nachweise

ORD-Eintrag
ord-dfb982258ce642ada7b089db16857294
Quelldatensatz
uspto-grants-2016_02
Patentnummer
US09249160B2

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