Triethylamine → 4-(2-Chloro-6-fluorobenzyl)-2-(2-methoxypyrimidin-5-yl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide
Reaktionsgleichung
[C:1](N1C=CN=C1)(N1C=CN=C1)=[O:2].C([N:15](CC)CC)C.[Cl:20][C:21]1[CH:48]=[CH:47][CH:46]=[C:45]([F:49])[C:22]=1[CH2:23][N:24]1[C:29]2[CH:30]=[CH:31][CH:32]=[CH:33][C:28]=2[S:27](=[O:35])(=[O:34])[N:26]([C:36]2[CH:41]=CC(=O)[N:38]([CH3:43])[CH:37]=2)[C:25]1=[O:44]>>[Cl:20][C:21]1[CH:48]=[CH:47][CH:46]=[C:45]([F:49])[C:22]=1[CH2:23][N:24]1[C:29]2[CH:30]=[CH:31][CH:32]=[CH:33][C:28]=2[S:27](=[O:35])(=[O:34])[N:26]([C:36]2[CH:41]=[N:15][C:43]([O:2][CH3:1])=[N:38][CH:37]=2)[C:25]1=[O:44]Komponenten
4
Edukt 3
Produkt 1
Versuchsvorschrift
The title compound (40 mg, 0.09 mmol) was prepared from (IntB2) (106 mg), 1,1′-carbonyldiimidazole (162 mg, 1.0 mmol) and triethylamine (0.07 mL, 0.50 mmol) using the methods of (132).