Ethyl Acetate → 4-(4-Chloro-3-ethylphenoxy)-1-nitrobenzene

HRID 17736

Reaktionsgleichung

Reaktionsgleichung von HRID 17736
F[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+].[Cl:17][C:18]1[CH:23]=[CH:22][C:21]([OH:24])=[CH:20][C:19]=1[CH2:25][CH3:26].CCOC(C)=O>CN(C=O)C>[Cl:17][C:18]1[CH:23]=[CH:22][C:21]([O:24][C:2]2[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][CH:3]=2)=[CH:20][C:19]=1[CH2:25][CH3:26]

Komponenten

6

Edukt 4

HCID 8857Ethyl AcetateHCID 9590p-FluoronitrobenzeneHCID 11430Potassium CarbonateHCID 842234-Chloro-3-ethylphenol

Produkt 1

HCID 669775234-(4-Chloro-3-ethylphenoxy)-1-nitrobenzene

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

To a stirred solution of 1-fluoro-4-nitrobenzene (10 mmol) in DMF (20 mL) at rt, solid potassium carbonate (30 mmol) was added followed by addition of 4-chloro-3-ethylphenol (10 mmol) to the reaction mixture and heating to 80° C. until the reaction was complete as indicated by TLC or HPLC. After cooling to rt, the reaction mixture was poured into EtOAc (100 mL), washed with H2O (2×50 mL) and brine (50 mL), and dried over sodium sulfate. The solvent was removed in vacuuo to afford the desired 4-(4-chloro-3-ethylphenoxy)-1-nitrobenzene. The crude product was used for further transformation.

Aufarbeitung

  1. temperatureAfter cooling to rt
  2. washwashed with H2O (2×50 mL) and brine (50 mL)
  3. dry with materialdried over sodium sulfate
  4. customThe solvent was removed in vacuuo

Quellen und Nachweise

ORD-Eintrag
ord-c9b591b7bdb2490a88e07295fec5b175
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07737285B2

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