Oxalic Acid → 2-benzylsulfanyl-4-(1-methylpiperidin-4-yloxy)-9,10-dihydro-4H-3,10a-diaza-benzo[f]azulene oxalate

HRID 1773877Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1773877
[CH2:1]([S:8][C:9]1[N:18]=[C:17]2[N:11]([CH2:12][CH2:13][C:14]3[CH:30]=[CH:29][CH:28]=[CH:27][C:15]=3[CH:16]2[O:19][CH:20]2[CH2:25][CH2:24][N:23]([CH3:26])[CH2:22][CH2:21]2)[CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:31]([OH:36])(=[O:35])[C:32]([OH:34])=[O:33]>CC(C)=O>[C:31]([OH:36])(=[O:35])[C:32]([OH:34])=[O:33].[CH2:1]([S:8][C:9]1[N:18]=[C:17]2[N:11]([CH2:12][CH2:13][C:14]3[CH:30]=[CH:29][CH:28]=[CH:27][C:15]=3[CH:16]2[O:19][CH:20]2[CH2:25][CH2:24][N:23]([CH3:26])[CH2:22][CH2:21]2)[CH:10]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Komponenten

4

Edukt 2

HCID 971Oxalic AcidHCID 726947772-benzylsulfanyl-4-(1-methylpiperidin-4-yloxy)-9,10-dihydro-4H-3,10a-diaza-benzo[f]azulene

Produkt 1

HCID 867039602-benzylsulfanyl-4-(1-methylpiperidin-4-yloxy)-9,10-dihydro-4H-3,10a-diaza-benzo[f]azulene oxalate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

2-benzylsulfanyl-4-(1-methylpiperidin-4-yloxy)-9,10-dihydro-4H-3,10a-diaza-benzo[f]azulene is dissolved in acetone (0.7 mL) and oxalic acid (1 equivalent) is added. Acetone is removed under reduced pressure to afford the product as an oxalate.

Aufarbeitung

  1. customAcetone is removed under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-1796522c75194388a1bf29e91695c0b0
Quelldatensatz
uspto-grants-2016_02
Patentnummer
US09255101B2

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