Methyl iodide → 6-Bromo-7-fluoro-1-methyl-3,4-dihydro-1H-quinolin-2-one

HRID 1774752Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1774752
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[F:12])[NH:8][C:7](=[O:13])[CH2:6][CH2:5]2.CI.[CH3:16]C(C)([O-])C.[K+]>>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[F:12])[N:8]([CH3:16])[C:7](=[O:13])[CH2:6][CH2:5]2

Komponenten

4

Edukt 3

HCID 6328Methyl iodideHCID 23665647Potassium tert-butoxideHCID 434576896-bromo-7-fluoro-3,4-dihydroquinolin-2(1H)-one

Produkt 1

HCID 866791306-Bromo-7-fluoro-1-methyl-3,4-dihydro-1H-quinolin-2-one

Versuchsvorschrift

In analogy to the procedure described for the preparation of intermediates A-1 [A], 6-bromo-7-fluoro-3,4-dihydro-1H-quinolin-2-one was reacted with methyl iodide in presence of potassium tert-butoxide to give the title compound as a white foam. MS: 258.0, 259.9 (M+H+).

Quellen und Nachweise

ORD-Eintrag
ord-549ee427621a4463b9d21615c0191f7a
Quelldatensatz
uspto-grants-2016_02
Patentnummer
US09260408B2

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