Hydrochloric Acid → 6-(5-Aminomethyl-4-chloro-pyridin-3-yl)-1-methyl-3,4-dihydro-1H-quinolin-2-one hydrochloride

HRID 1774858Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1774858
[Cl:1][C:2]1[C:7]([C:8]2[CH:9]=[C:10]3[C:15](=[CH:16][CH:17]=2)[N:14]([CH3:18])[C:13](=[O:19])[CH2:12][CH2:11]3)=[CH:6][N:5]=[CH:4][C:3]=1[CH2:20][NH:21][S@@](C(C)(C)C)=O.Cl>CO>[ClH:1].[NH2:21][CH2:20][C:3]1[C:2]([Cl:1])=[C:7]([C:8]2[CH:9]=[C:10]3[C:15](=[CH:16][CH:17]=2)[N:14]([CH3:18])[C:13](=[O:19])[CH2:12][CH2:11]3)[CH:6]=[N:5][CH:4]=1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 86679199(R)-2-Methyl-propane-2-sulfinic acid [4-chloro-5-(1-methyl-2-oxo-1,2,3,4-tetrahydro-quinolin-6-yl)-pyridin-3-ylmethyl]-amide

Produkt 1

HCID 866792006-(5-Aminomethyl-4-chloro-pyridin-3-yl)-1-methyl-3,4-dihydro-1H-quinolin-2-one hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

In analogy to the procedure described for the preparation of example 42, reaction of (R)-2-methyl-propane-2-sulfinic acid [4-chloro-5-(1-methyl-2-oxo-1,2,3,4-tetrahydro-quinolin-6-yl)-pyridin-3-ylmethyl]-amide (example 217) with hydrogen chloride (in dixoane) in methanol gave the title compound as a yellow solid. MS: 302.4 (M+H+).

Quellen und Nachweise

ORD-Eintrag
ord-767443bd5dea46e3a0f7513923cebd02
Quelldatensatz
uspto-grants-2016_02
Patentnummer
US09260408B2

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