L-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]- → HCID 136242931, Verbindung
Reaktionsgleichung
[CH2:1]1[NH:13][CH2:12][C:11]2[NH:10][C:9]3[CH:8]=[CH:7][CH:6]=[C:5]4[C:14](=[O:17])[NH:15][N:16]=[C:2]1[C:3]=2[C:4]=34.[C:18]([O:22][C:23]([NH:25][C@@H:26]([CH2:30][C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1)[C:27](O)=[O:28])=[O:24])([CH3:21])([CH3:20])[CH3:19].NC(C)(C)C(N1CC2NC3C=CC=C4C(=O)NN=C(C=2C=34)C1)=O>>[C:18]([O:22][C:23](=[O:24])[NH:25][C@@H:26]([CH2:30][C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1)[C:27](=[O:28])[N:13]1[CH2:12][C:11]2[NH:10][C:9]3[CH:8]=[CH:7][CH:6]=[C:5]4[C:14](=[O:17])[NH:15][N:16]=[C:2]([C:3]=2[C:4]=34)[CH2:1]1)([CH3:21])([CH3:19])[CH3:20]Komponenten
4
Versuchsvorschrift
Compound 63 was prepared from 2,3,4,9-tetrahydro-2,4,9,10-tetraazacyclohepta[def]fluoren-8(1H)-one and (S)-2-((tert-butoxycarbonyl)amino)-3-phenylpropanoic acid to the procedure similar to that for Compound 62. 1H NMR (DMSO-d6) δ 11.8 (s, 1H), 10.0 (s, 1H), 7.51 (d, 1H, J=8.0 Hz), 7.05-7.47 (m, 7H), 4.96-5.02 (m, 1H), 4.25-4.81 (m, 4H), 2.62-2.88 (m, 2H), 1.27 (s, 6H), and 1.16 (s, 3H). MS (ESI) m/e [M+1]+ 474.