Hydrochloric Acid → 2-Methyl-3-(piperidin-4-yl)pyridine hydrochloride
Reaktionsgleichung
[CH3:1][C:2]1[C:7]([CH:8]2[CH2:13][CH2:12][N:11](C(OC(C)(C)C)=O)[CH2:10][CH2:9]2)=[CH:6][CH:5]=[CH:4][N:3]=1.[ClH:21]>CO>[ClH:21].[CH3:1][C:2]1[C:7]([CH:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)=[CH:6][CH:5]=[CH:4][N:3]=1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
tert-Butyl 4-(2-methyl-3-pyridyl)piperidine-1-carboxylate (100 mg, 0.36 mmol) was dissolved in methanol (4 ml) and combined with hydrochloric acid (4N in dioxane, 10 ml) and the mixture was stirred at room temperature for two hours. The volatiles were removed under reduced pressure to yield 54 mg of a beige solid (0.25 mmol, 69%) MS (ESI) m/z=177.1 [M+1]+.
Aufarbeitung
- customThe volatiles were removed under reduced pressure
Quellen und Nachweise
- ORD-Eintrag
- ord-ac158981a4d1402f8019e38bc8b14812
- Quelldatensatz
- uspto-grants-2016_02
- Patentnummer
- US09260441B2
Notizen zur Reaktion
Wird geladen…