HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
3-Bromoaniline → 3-(3-Bromophenyl)-7-phenylthieno[3,2-d]pyrimidin-4(3H)-one
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 3-Bromoaniline | HCID 11562 | — |
| Edukt | Ethyl orthoformate | HCID 31214 | — |
| Edukt | Methyl 3-amino-4-phenylthiophene-2-carboxylate | HCID 2759782 | — |
| Edukt | 3,7-Diphenylthieno[3,2-d]pyrimidin-4(3H)-one | HCID 78324865 | — |
| Lösungsmittel | Acetic Acid | HCID 176 | — |
| Produkt | 3-(3-Bromophenyl)-7-phenylthieno[3,2-d]pyrimidin-4(3H)-one | HCID 78324872 | 12% |
Reaktionsschritte
In the same manner as the synthesis of Compound 1, methyl 3-amino-4-phenylthiophene-2-carboxylate (200 mg, 0.86 mmol), triethyl orthoformate (2 ml), 3-bromoaniline (280 mg, 1.63 mmol), and acetic acid (0.2 ml) were used to give 40 mg (0.10 mmol, 12% yield) of the title compound.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US09260448B2 |
| Quelldatensatz | uspto-grants-2016_02 |
| ORD ID | ord-264be8b8c0e44d28a65ebf3d2377c035 |
| Quellennotiz | uspto-grants-2016_02 |