HCID 86699394, Verbindung → HCID 67974428, Verbindung

HRID 1777682Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1777682
[C:1]([C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[NH:8][C:7]([Si](CC)(CC)CC)=[C:6]2[CH2:19][CH2:20][NH:21][C:22](=[O:37])[C:23]1[CH:28]=[CH:27][C:26]([CH2:29][C:30]2[CH:35]=[CH:34][CH:33]=[C:32]([F:36])[CH:31]=2)=[CH:25][CH:24]=1)#[N:2]>FC(F)(F)C(O)=O>[C:1]([C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[NH:8][CH:7]=[C:6]2[CH2:19][CH2:20][NH:21][C:22](=[O:37])[C:23]1[CH:28]=[CH:27][C:26]([CH2:29][C:30]2[CH:35]=[CH:34][CH:33]=[C:32]([F:36])[CH:31]=2)=[CH:25][CH:24]=1)#[N:2]

Komponenten

3

Edukt 1

HCID 86699394HCID 86699394, Verbindung

Produkt 1

HCID 67974428HCID 67974428, VerbindungAusbeute 30 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6422Trifluoroacetic acidLösungsmittel

Versuchsvorschrift

N-(2-(5-Cyano-2-(triethylsilyl)-1H-indol-3-yl)ethyl)-4-(3-fluorobenzyl)benzamide (0.056 g; 0.109 mmol) was dissolved in trifluoroacetic acid (3 mL) and stirred at room temperature for 3 hours. The solution was concentrated under reduced pressure and the crude material was purified by flash chromatography on silica gel (eluent 20 to 100% ethyl acetate in heptane) to afford 0.013 g (29%) of the title compound as a white solid.

Aufarbeitung

  1. concentrationThe solution was concentrated under reduced pressure
  2. customthe crude material was purified by flash chromatography on silica gel (eluent 20 to 100% ethyl acetate in heptane)

Quellen und Nachweise

ORD-Eintrag
ord-44213f7d66bd481889016c6ae404f72e
Quelldatensatz
uspto-grants-2016_02
Patentnummer
US09266832B2

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