Chlorosuccinimide → HCID 89726263, Verbindung

HRID 1777735Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1777735
[N:1]1([CH2:10][C:11]([OH:13])=[O:12])[C:5]2=[N:6][CH:7]=[CH:8][CH:9]=[C:4]2[CH:3]=[CH:2]1.C1C(=O)N([Cl:21])C(=O)C1>CC#N>[Cl:21][C:3]1[C:4]2[C:5](=[N:6][CH:7]=[CH:8][CH:9]=2)[N:1]([CH2:10][C:11]([OH:13])=[O:12])[CH:2]=1

Komponenten

4

Edukt 2

HCID 31398ChlorosuccinimideHCID 22139374(1H-Pyrrolo[2,3-b]pyridin-1-yl)acetic acid

Produkt 1

HCID 89726263HCID 89726263, VerbindungAusbeute 77 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Reaktionsbedingungen

Temperatur
65 °C

Versuchsvorschrift

To a suspension of 2-(1H-pyrrolo[2,3-b]pyridin-1-yl)acetic acid (100 mg) in MeCN (10 mL) was added NCS (91 mg) and the reaction mixture was stirred at 60° C. overnight and at 65° C. for 20 h. The solvent was removed in vacuo, the residue was taken up in DCM and the resulting precipitate was filtered off. The precipitate was further washed with DCM and dried in vacuo. 92 mg of grey solid was obtained. LC-MS (B): tR=0.66 min; [M+H]+: 211.02.

Aufarbeitung

  1. customThe solvent was removed in vacuo
  2. filtrationthe resulting precipitate was filtered off
  3. washThe precipitate was further washed with DCM
  4. customdried in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-239a59c217984798aad5e05da56dbf7a
Quelldatensatz
uspto-grants-2016_02
Patentnummer
US09266876B2

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