Trifluoroacetic acid → HCID 178515443, Verbindung

Into a 100-mL round-bottom flask, was placed a solution of [4-bromo-2-(tert-butoxy)quinolin-6-yl]bis(4-chlorophenyl)methanol (1.5 g, 2.82 mmol, 1.00 equip) in dichloromethane (55 mL), Et3SiH (1.3 g, 4.00 equip), and trifluoroacetic acid (8 g, 70.77 mmol, 25.00 equip). The resulting solution was stirred overnight at room temperature. The pH value of the solution was adjusted to 7-8 with sodium bicarbonate. The resulting solution was extracted with DCM (3×50 ml) and the organic layers combined. The resulting mixture was washed with water (2×50 mL). The resulting mixture was washed with brine (1×50 mL). The resulting mixture was dried over anhydrous sodium sulfate and concentrated to yield 6-[bis(4-chlorophenyl)methyl]-4-bromoquinolin-2-ol as a white solid. (ES, m/z): [M+H]+ 433

1. customInto a 100-mL round-bottom flask, was placed
2. extractionThe resulting solution was extracted with DCM (3×50 ml)
3. washThe resulting mixture was washed with water (2×50 mL)
4. washThe resulting mixture was washed with brine (1×50 mL)
5. dry with materialThe resulting mixture was dried over anhydrous sodium sulfate
6. concentrationconcentrated

ORD-Eintrag

ord-34a1ffa7769a4808b01924bad72f95b2

Quelldatensatz

uspto-grants-2016_02

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US09266835B2