3,4-Difluorobenzaldehyde → 4-(3,4-Difluoro-phenyl)-6-methyl-2-thiazol-2-yl-1,4-dihydro-pyrimidine-5-carboxylic acid methyl ester

HRID 1778460Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1778460
[CH3:1][O:2][C:3]([C:5]1[CH:6]([C:17]2[CH:22]=[CH:21][C:20]([F:23])=[CH:19][C:18]=2Cl)[N:7]=[C:8]([C:12]2[S:13][CH:14]=[CH:15][N:16]=2)[NH:9][C:10]=1[CH3:11])=[O:4].[F:25]C1C=C(C=CC=1F)C=O>>[CH3:1][O:2][C:3]([C:5]1[CH:6]([C:17]2[CH:22]=[CH:21][C:20]([F:23])=[C:19]([F:25])[CH:18]=2)[N:7]=[C:8]([C:12]2[S:13][CH:14]=[CH:15][N:16]=2)[NH:9][C:10]=1[CH3:11])=[O:4]

Komponenten

3

Edukt 2

HCID 5880883,4-DifluorobenzaldehydeHCID 9820500Methyl 4-(2-Chloro-4-fluorophenyl)-6-methyl-2-(2-thiazolyl)-1,4-dihydropyrimidine-5-carboxylate

Produkt 1

HCID 1177003064-(3,4-Difluoro-phenyl)-6-methyl-2-thiazol-2-yl-1,4-dihydro-pyrimidine-5-carboxylic acid methyl ester

Versuchsvorschrift

Compound D was prepared in analogy to Compound B with the procedure shown in Scheme 3 by using 3,4-difluoro-benzaldehye instead of 2-chloro-5-fluorobenzaldehyde.

Quellen und Nachweise

ORD-Eintrag
ord-d245d62f3c734af9934790bd54f68b6a
Quelldatensatz
uspto-grants-2016_02
Patentnummer
US09266904B2

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