Methanol → Methyl cycloheptanecarboxylate
Reaktionsgleichung
[CH:1]1([C:8]([OH:10])=[O:9])[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.OS(O)(=O)=O.[CH3:16]O>>[CH:1]1([C:8]([O:10][CH3:16])=[O:9])[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1Komponenten
4
Versuchsvorschrift
To a solution of 25.0 g cycloheptanecarboxylic acid in methanol (300 mL) was added concentrated H2SO4 (0.5 g) and the mixture was stirred at reflux overnight. The reaction mixture was concentrated under vacuum and the residue was diluted with ethyl ether (500 mL). The mixture was washed with water and brine, dried over Na2SO4, filtered, and concentrated under reduced pressure to give the title compound.
Aufarbeitung
- temperatureat reflux overnight
- concentrationThe reaction mixture was concentrated under vacuum
- additionthe residue was diluted with ethyl ether (500 mL)
- washThe mixture was washed with water and brine
- dry with materialdried over Na2SO4
- filtrationfiltered
- concentrationconcentrated under reduced pressure
Quellen und Nachweise
- ORD-Eintrag
- ord-0c14c293546d4e46b03446b45dfb9dd9
- Quelldatensatz
- uspto-grants-2016_02
- Patentnummer
- US09266877B2
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