Trifluoroacetic acid → HCID 19047187, Verbindung
Reaktionsgleichung
[CH3:1][C:2]1[CH:3]=[C:4]([S:7][CH2:8][CH:9]=[C:10]([CH3:12])[CH3:11])[S:5][CH:6]=1.FC(F)(F)C(O)=O>C(Cl)Cl>[CH3:1][C:2]1[C:3]2[C:10]([CH3:12])([CH3:11])[CH2:9][CH2:8][S:7][C:4]=2[S:5][CH:6]=1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
A solution of 17.36 g (0.088 mol) of the title compound of Step A in 300 mL of methylene chloride was added dropwise to 300 mL of trifluoroacetic acid under nitrogen. After stirring at room temperature overnight, the mixture was evaporated to dryness. The residue was dissolved in 500 mL of methylene chloride, washed with 5% sodium bicarbonate (2×500 mL), dried (MgSO4), filtered, and evaporated to dryness. The crude product was chromatographed on silica gel eluting with hexane to yield 8.26 g of the title compound of Step B as an oil. 1H NMR (CDCl3): δ 1.32 (s,6H), 2.0 (m,2H), 2.3 (s,3H), 3.0 (m,2H), 6.6 (s, 1H).