Pyridine → HCID 18973686, Verbindung

HRID 1780840Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1780840
[CH:1]1([CH2:4][O:5][C:6]2[CH:7]=[C:8](O)[CH:9]=[CH:10][C:11]=2[O:12][CH:13]([F:15])[F:14])[CH2:3][CH2:2]1.N1C=CC=CC=1.S(Cl)(Cl)=O.[CH:27](Cl)(Cl)[Cl:28]>>[CH:1]1([CH2:4][O:5][C:6]2[CH:7]=[C:8]([CH:9]=[CH:10][C:11]=2[O:12][CH:13]([F:15])[F:14])[CH2:27][Cl:28])[CH2:3][CH2:2]1

Komponenten

5

Edukt 4

HCID 1049PyridineHCID 6212ChloroformHCID 24386Thionyl ChlorideHCID 54134609HCID 54134609, Verbindung

Produkt 1

HCID 18973686HCID 18973686, Verbindung

Versuchsvorschrift

A solution of crude 3-cyclopropylmethoxy-4-difluoromethoxyphenyl alcohol (24.4 g) and pyridine (9.8 mL, 120 mmol) in chloroform (150 mL) under an argon atmosphere was treated with thionyl chloride (8.0 mL, 110 mmol) and the mixture was heated at reflux for 1 h. The solvent was removed, ether was added and the precipitate was removed by filtration. The filtrate was concentrated to a pale yellow oil (26 g).

Aufarbeitung

  1. temperaturethe mixture was heated
  2. temperatureat reflux for 1 h
  3. customThe solvent was removed
  4. additionether was added
  5. customthe precipitate was removed by filtration
  6. concentrationThe filtrate was concentrated to a pale yellow oil (26 g)

Quellen und Nachweise

ORD-Eintrag
ord-aa781d988aae4b8081c468563e72552e
Quelldatensatz
uspto-grants-1997_05
Patentnummer
US05631286

Notizen zur Reaktion

Wird geladen…