Hexahydro-1-methyl-4-[1-(phenylmethyl)-4-piperidinyl]-1H-1,4-diazepine → Hexahydro-1-methyl-4-(4-piperidinyl)-1H-1 4-diazepine

HRID 1782722Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1782722
[CH3:1][N:2]1[CH2:8][CH2:7][CH2:6][N:5]([CH:9]2[CH2:14][CH2:13][N:12](CC3C=CC=CC=3)[CH2:11][CH2:10]2)[CH2:4][CH2:3]1>[OH-].[OH-].[Pd+2]>[CH3:1][N:2]1[CH2:8][CH2:7][CH2:6][N:5]([CH:9]2[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)[CH2:4][CH2:3]1

Komponenten

3

Edukt 1

HCID 18321160Hexahydro-1-methyl-4-[1-(phenylmethyl)-4-piperidinyl]-1H-1,4-diazepine

Produkt 1

HCID 18321176Hexahydro-1-methyl-4-(4-piperidinyl)-1H-1 4-diazepine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 9942167Palladium hydroxideKatalysator

Versuchsvorschrift

Prepared analogously to Example A3f) from hexahydro-1-methyl-4-[1-(phenylmethyl)-4-piperidinyl]-1H-1,4-diazepine by hydrogenolysis, but using Pearlman's catalyst instead of palladium/charcoal, in a quantitative yield. Colourless viscous oil.

Quellen und Nachweise

ORD-Eintrag
ord-94fcb51b47c845f0ae6891a69974f9e6
Quelldatensatz
uspto-grants-2009_03
Patentnummer
US07498325B2

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