Methylhydrazine → HCID 23084651, Verbindung

HRID 1783300Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1783300
[C:1]([CH:4]([C:7]1[CH:12]=[CH:11][C:10]([F:13])=[CH:9][CH:8]=1)[C:5]#[N:6])(=O)[CH3:2].[CH3:14][NH:15][NH2:16]>C(O)C>[NH2:6][C:5]1[N:15]([CH3:14])[N:16]=[C:1]([CH3:2])[C:4]=1[C:7]1[CH:12]=[CH:11][C:10]([F:13])=[CH:9][CH:8]=1

Komponenten

4

Edukt 2

HCID 6061MethylhydrazineHCID 30138862-(4-Fluorophenyl)-3-oxobutanenitrile

Produkt 1

HCID 23084651HCID 23084651, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

α-Acetyl-4-fluorophenylacetonitrile (65.1 g) and methylhydrazine (30.9 mL) were dissolved in ethanol (320 mL), and the mixture was heated under reflux for 3 hrs. After the completion of the reaction, the reaction mixture was cooled to room temperature, and the solvent was evaporated. The obtained solid was collected by filtration and washed with hexane to give 5-amino-4-(4-fluorophenyl)-1,3-dimethylpyrazole (69.5 g).

Aufarbeitung

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 3 hrs
  3. customAfter the completion of the reaction
  4. customthe solvent was evaporated
  5. filtrationThe obtained solid was collected by filtration
  6. washwashed with hexane

Quellen und Nachweise

ORD-Eintrag
ord-cddb9af07abf41b494cfeb8ed3d46cb9
Quelldatensatz
uspto-grants-2009_03
Patentnummer
US07501412B2

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