Hydrochloric Acid → HCID 178516641, Verbindung

HRID 1783335Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1783335
[O-]CC.[Na+].[Cl:5][C:6]1[CH:14]=[CH:13][C:9]([C:10]([NH2:12])=[NH:11])=[CH:8][CH:7]=1.[C:15](OCC)(=[O:22])[CH2:16][C:17](OCC)=[O:18].Cl>C(O)C>[Cl:5][C:6]1[CH:14]=[CH:13][C:9]([C:10]2[N:12]=[C:17]([OH:18])[CH:16]=[C:15]([OH:22])[N:11]=2)=[CH:8][CH:7]=1

Komponenten

6

Edukt 4

HCID 313Hydrochloric AcidHCID 7761Diethyl MalonateHCID 2034374-ChlorobenzamidineHCID 2723922Sodium ethoxide

Produkt 1

HCID 178516641HCID 178516641, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel2×

Reaktionsbedingungen

Temperatur
40 °C

Versuchsvorschrift

To sodium ethoxide (48 ml of a 21% wt solution in ethanol diluted with a further 130 ml ethanol) was added 4-chlorobenzamidine (8 g) and diethyl malonate (6.67 ml) and the solution left to stir at 40° C. for 96 hrs. The reaction mixture was subsequently cooled to 5° C. and acidified cautiously to pH 2 using concentrated hydrochloric acid. The solid thus precipitated was filtered, washed with excess cold water, then 50 ml diethyl ether and dried in vacuo yielding the title compound (7.51 g).

Aufarbeitung

  1. waitthe solution left
  2. temperatureThe reaction mixture was subsequently cooled to 5° C.
  3. customThe solid thus precipitated
  4. filtrationwas filtered
  5. washwashed with excess cold water
  6. dry with material50 ml diethyl ether and dried in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-9dd16eab2b6941edbbcb5c059d77f0a9
Quelldatensatz
uspto-grants-2009_03
Patentnummer
US07501407B2

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