Trifluoroacetic acid → 2-Chloro-3,5-Dimethoxyaniline

HRID 1783548

Reaktionsgleichung

Reaktionsgleichung von HRID 1783548
C(OC(=O)[NH:7][C:8]1[CH:13]=[C:12]([O:14][CH3:15])[CH:11]=[C:10]([O:16][CH3:17])[C:9]=1[Cl:18])(C)(C)C.FC(F)(F)C(O)=O>>[Cl:18][C:9]1[C:10]([O:16][CH3:17])=[CH:11][C:12]([O:14][CH3:15])=[CH:13][C:8]=1[NH2:7]

Komponenten

3

Edukt 2

HCID 6422Trifluoroacetic acidHCID 54265450HCID 54265450, Verbindung

Produkt 1

HCID 227430742-Chloro-3,5-DimethoxyanilineAusbeute 101.012,797 %

Versuchsvorschrift

To 6.01 g (0.021 mmol) of (2-chloro-3,5-dimethoxy-phenyl)-carbamic acid tert-butyl ester was added 15 mL of trifluoroacetic acid. The reaction was stirred for 3 hours at room temperature, then concentrated in vacuo. The residue was made basic with a saturated solution of sodium bicarbonate, then extracted three times with dichloromethane. The combined dichloromethane layers were dried with magnesium sulfate and concentrated in vacuo to give 3.98 g of the title compound, which was used as is in the following example.

Aufarbeitung

  1. concentrationconcentrated in vacuo
  2. extractionextracted three times with dichloromethane
  3. dry with materialThe combined dichloromethane layers were dried with magnesium sulfate
  4. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-c7d2e9ad817e419e9dccae79ac1fec04
Quelldatensatz
uspto-grants-2009_03
Patentnummer
US07501425B1

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