Methylamine → 4-Bromo-N-methylthiazole-2-carboxamide

HRID 1783964Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1783964
C([O:3][C:4]([C:6]1[S:7][CH:8]=[C:9]([Br:11])[N:10]=1)=O)C.[CH3:12][NH2:13]>CO>[CH3:12][NH:13][C:4]([C:6]1[S:7][CH:8]=[C:9]([Br:11])[N:10]=1)=[O:3]

Komponenten

4

Edukt 2

HCID 6329MethylamineHCID 49757955Ethyl 4-bromothiazole-2-carboxylate

Produkt 1

HCID 575900864-Bromo-N-methylthiazole-2-carboxamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel2×

Versuchsvorschrift

4-Bromothiazole-2-carboxylic acid ethyl ester (500 mg, 2.13 mmol) is dissolved in methanol (1 mL) and methyl amine in methanol (10 mL) is added. The mixture is stirred overnight at room temperature. Evaporation of the solvent under reduced pressure affords the title compound as yellow solid. LCMS: Rt 0.92 min (100%) m/z (ESI) 219/221 (M+H)+.

Aufarbeitung

  1. customEvaporation of the solvent under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-d3bbd687e934429f83c1107e159f79da
Quelldatensatz
uspto-grants-2009_03
Patentnummer
US07501411B2

Notizen zur Reaktion

Wird geladen…