Acetic Anhydride → (4-Bromopyridin-2-yl)methyl acetate

Beteiligte Stoffe

Reaktionsschritte

To a solution of 4-bromo-2-methylpyridine-1-oxide (4.00 g, 21.40 mmol) in DCM (20 mL) is added acetic anhydride (6 mL). The mixture is stirred at room temperature for 1 hour and then heated at reflux overnight. The solvent is removed under vacuum and the crude product is filtered through a silica plug, eluting with DCM to afford the title compound as an orange oil (815 mg).

Herkunft & Nachweise