Acetic Anhydride → (4-Bromopyridin-2-yl)methyl acetate

HRID 1783976

Reaktionsgleichung

Reaktionsgleichung von HRID 1783976
[Br:1][C:2]1[CH:7]=[CH:6][N+:5]([O-])=[C:4]([CH3:9])[CH:3]=1.[C:10]([O:13]C(=O)C)(=[O:12])[CH3:11]>C(Cl)Cl>[Br:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([CH2:9][O:13][C:10](=[O:12])[CH3:11])[CH:3]=1

Komponenten

4

Edukt 2

HCID 7918Acetic AnhydrideHCID 544461394-Bromo-2-methyl-1-oxo-1lambda~5~-pyridine

Produkt 1

HCID 45789873(4-Bromopyridin-2-yl)methyl acetate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a solution of 4-bromo-2-methylpyridine-1-oxide (4.00 g, 21.40 mmol) in DCM (20 mL) is added acetic anhydride (6 mL). The mixture is stirred at room temperature for 1 hour and then heated at reflux overnight. The solvent is removed under vacuum and the crude product is filtered through a silica plug, eluting with DCM to afford the title compound as an orange oil (815 mg).

Aufarbeitung

  1. temperatureheated
  2. temperatureat reflux overnight
  3. customThe solvent is removed under vacuum
  4. filtrationthe crude product is filtered through a silica plug
  5. washeluting with DCM

Quellen und Nachweise

ORD-Eintrag
ord-0c44e6b863894bd3bbec0160a1725659
Quelldatensatz
uspto-grants-2009_03
Patentnummer
US07501411B2

Verknüpfte Notizen

Wird geladen…