2-Amino-5-nitropyridine → HCID 23120526, Verbindung

HRID 1784732Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1784732
[O:1]1[CH2:5][CH2:4][CH:3]([C:6](=O)[CH2:7][CH3:8])[CH2:2]1.[NH2:10][C:11]1[CH:16]=[CH:15][C:14]([N+:17]([O-:19])=[O:18])=[CH:13][N:12]=1>C(OCC)(=O)C>[CH3:8][C:7]1[N:12]2[CH:13]=[C:14]([N+:17]([O-:19])=[O:18])[CH:15]=[CH:16][C:11]2=[N:10][C:6]=1[CH:3]1[CH2:4][CH2:5][O:1][CH2:2]1

Komponenten

4

Edukt 2

HCID 778882-Amino-5-nitropyridineHCID 21702750HCID 21702750, Verbindung

Produkt 1

HCID 23120526HCID 23120526, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

Operations similar to Production Example 1-(1) were conducted using 1-tetrahydro-3-furanyl-1-propanone in place of 3-methyl-2-butanone, and successively those of Production Example 1-(2) were conducted using 2-amino-5-nitropyridine. The resulting solid was suspended in ethyl acetate, washed with saturated aqueous sodium hydrogencarbonate solution and purified by silica gel column chromatography (hexane/ethyl acetate=2/1) to provide the title compound as yellow crystals.

Aufarbeitung

  1. washwashed with saturated aqueous sodium hydrogencarbonate solution
  2. custompurified by silica gel column chromatography (hexane/ethyl acetate=2/1)

Quellen und Nachweise

ORD-Eintrag
ord-6adc145dc9574a5abe15a17244a23aab
Quelldatensatz
uspto-grants-2009_03
Patentnummer
US07504412B2

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