[2-(3-Cyano-phenyl)-1-methyl-ethyl]-carbamic acid tert-butyl ester → 3-(2-Amino-propyl)-benzonitrile

HRID 1785426Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1785426
C(OC(=O)[NH:7][CH:8]([CH3:18])[CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[C:12]([C:16]#[N:17])[CH:11]=1)(C)(C)C>ClCCl.FC(F)(F)C(O)=O>[NH2:7][CH:8]([CH3:18])[CH2:9][C:10]1[CH:11]=[C:12]([CH:13]=[CH:14][CH:15]=1)[C:16]#[N:17]

Komponenten

4

Edukt 1

HCID 69068307[2-(3-Cyano-phenyl)-1-methyl-ethyl]-carbamic acid tert-butyl ester

Produkt 1

HCID 575931503-(2-Amino-propyl)-benzonitrile

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6344DichloromethaneLösungsmittelHCID 6422Trifluoroacetic acidLösungsmittel

Versuchsvorschrift

A solution of [2-(3-Cyano-phenyl) -1-methyl-ethyl]-carbamic acid tert-butyl ester (180 mg, 0.69 mmol) in dichloromethane (5 mL) and trifluoroacetic acid (5 mL) was stirred for 15 min at room temperature. Solvents removed under vacuum, and residue was partitioned between dichloromethane and 1 N sodium hydroxide. Organic dried over magnesium sulfate and reduced to an oil under vacuum. M+1=161.

Aufarbeitung

  1. customSolvents removed under vacuum, and residue
  2. customwas partitioned between dichloromethane and 1 N sodium hydroxide
  3. dry with materialOrganic dried over magnesium sulfate

Quellen und Nachweise

ORD-Eintrag
ord-8eed1f6741c94565b214f88940a313f8
Quelldatensatz
uspto-grants-2009_03
Patentnummer
US07504403B2

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